Dr. Mirvat El-Sibai's Lab

Journal Articles

1. Khoury N, El-Hayek S, Tarras O, El-Sabban M, El-Sibai M, Rizk S. Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion.Int J Oncol. 2014 Nov;45(5):2117-27. doi: 10.3892/ijo.2014.2635. Epub 2014 Sep 3.


2. Saykali BA, El-Sibai M. Invadopodia, regulation, and assembly in cancer cell invasion.Cell Commun Adhes. 2014 Aug;21(4):207-12.


3. Nasrallah A. and El-Sibai M. Colorectal Cancer Causes and Treatments: A minireview. Open Colorectal Cancer Journal pp 1-4 Published Date: 21 February, 2014. [DOI: 10.2174/1876820201407010001]


4. Al-Dimassi S., Abou-Antoun T. and El-Sibai M. Cancer Cell Resistance Mechanisms: A minireview. Clinical and Translational Oncology (2014) DOI: 10.1007/s12094-014-1162-1.


5.  Hanna S., Khalil B.D., Saykali B., Nasrallah A., Sobh R., Nasser S. and El-Sibai M. StarD13 is a Tumor Suppressor in Breast Cancer Needed for Cell Motility and Invasion. Int J Oncol. 2014


6. Najm P. and El-Sibai M. Palladin regulation of the actin structures needed for cancer invasion. Cell Adh Migr. 2013 Jan 1;8(1). [Epub ahead of print] Review.


7. Khalil BD, Hanna S, Saykali BA, El-Sitt S, Nasrallah A, Marston D, El-Sabban M, Hahn KM, Symons M, El-Sibai M.

Exp Cell Res. 2014 Feb 15;321(2):109-22. doi: 10.1016/j.yexcr.2013.11.023. Epub 2013 Dec 10.


8. Nasrallah A, Saykali B, Al Dimassi S, Khoury N, Hanna S, El-Sibai M.

Oncol Rep. 2014 Jan;31(1):505-15. doi: 10.3892/or.2013.2861. Epub 2013 Nov 20.


9. Hanna S, El-Sibai M.

Cell Signal. 2013 Oct;25(10):1955-61. doi: 10.1016/j.cellsig.2013.04.009. Epub 2013 May 11.


10. El-Sitt S, El-Sibai M.

J Recept Signal Transduct Res. 2013;33(1):10-3. doi: 10.3109/10799893.2012.752002. Epub 2013 Jan 15. Review.


11. Shebaby WN, El-Sibai M, Smith KB, Karam MC, Mroueh M, Daher CF.

Phytother Res. 2013 May;27(5):737-44. doi: 10.1002/ptr.4776. Epub 2012 Jul 20.


12. El-Sitt S, Khalil BD, Hanna S, El-Sabban M, Fakhreddine N, El-Sibai M.

Oncol Rep. 2012 Aug;28(2):511-8. doi: 10.3892/or.2012.1819. Epub 2012 May 17.


13. Khalil BD, El-Sibai M.

J Neurooncol. 2012 Jul;108(3):333-9. doi: 10.1007/s11060-012-0866-8. Epub 2012 Apr 19. Review.


14. Bahnan W., Koussa J., Younes S., Abi Rizk M., Khalil B., El-Sitt M., Hanna S., El-Sibai M. and Khalaf R.A. Deletion of the Candida albicans PIR32 results in increased virulence, stress response, and upregulation of cell wall chitin deposition. Mycopathologia. 2012 Mar 6. [Epub ahead of print].


15. Alwan A.; Youhanna S.C.; Platt D.E.; El-Sibai M.; Yerezian J.S.; Deeb M.; Khazen G.; Saade S.; Zreik T.G.; El Bayeh H.; Maalouf A.; Abchee A. and Zalloua P.A. ALOX5AP Gene Variants Show Differential Association with Coronary Artery Disease In Different Populations. Journal of Community Genetics, 2010. DOI: 10.1007/s12687-010-0015-z.


16. Haber M, Platt DE, Badro DA, Xue Y, El-Sibai M, Bonab MA, Youhanna SC, Saade S, Soria-Hernanz DF, Royyuru A, Wells RS, Tyler-Smith C, Zalloua PA; The Genographic Consortium. Influences of history, geography, and religion on genetic structure: the Maronites in Lebanon. Eur J Hum Genet. Eur J Hum Genet. 2011 Mar;19(3):334-40. Epub 2010 Dec


17. Abchee A., El-Sibai M., Youhanna S.C., Estephan H., Makhoul N.J., Puzantian H., Sawaya J., Nasrallah A., Rebeiz A.G., Zreik T.G., Azar S.T. and Zalloua P.A. The I allele of The Angiotensin Converting Enzyme I/D Polymorphism Confers Protection against Coronary Artery Disease. Coron Artery Dis. 2010 Mar 17.


18. Wu H, Shekar SC, Flinn RJ, El-Sibai M, Jaiswal BS, Sen KI, Janakiraman V, Seshagiri S, Gerfen GJ, Girvin ME, Backer JM. Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants. Proc Natl Acad Sci U S A. 2009 Dec 1


19. El-Sibai M., Platt DE, Haber M, Xue Y, Youhanna SC, R. Wells RS, Izaabel H, Sanyoura MF,Harmanani H, Bonab MA, Behbehani J., Hashwa F., Tyler-Smith C, Zalloua PA and The Genographic Consortium. Geographical aspects of the Y-chromosomal genetic landscape of the Levant: a coastal-inland contrast. Ann Hum Genet. 2009 Aug 16.


20. Zalloua PA, Platt DE, El-Sibai M., Khalife J, Makhoul N, Haber M, Xue Y, Izaabel H, Bosch E, Adams SM, Arroyo E, López-Parra AM, Aler M, Picornell A, Ramon M, Jobling MA, Comas D, Bertranpetit J, Wells RS, Tyler-Smith C; The Genographic Consortium. Identifying Genetic Traces of Historical Expansions: Phoenician Footprints in the Mediterranean. Am J Hum Genet. 2008 Oct 29.

Featured in NYTimes (http://www.nytimes.com/2008/10/31/science/31genes.html) and several other media outlets (Reuters, associated press, Washington post, BBC etc.)


21. El-Sibai M., Pertz, O., Pang, H., Yip, S.C., Lorenz, M., Symons, M., Condeelis, J.S., Hahn, K.M., and Backer, J.M. RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells. (2008) Exp. Cell Res. 314:1540-52


22. Sarmiento C., Yamaguchi H., Wang W., El-Sibai M., DesMarais V., Holman H.A., Kitchen S., Alberts A. and Condeelis J.S. The role of WASP family members and Formins in actin reorganization in cell protrusions. J Cell Biol. 2008 Mar 24;180(6):1245-60.


23.  Sidani M., Wessels D., Mouneimne G., Ghosh M., Goswami S., Sarmiento C., Wang W., Kuhl S., El-Sibai M., Backer JM., Eddy R., Soll D. and Condeelis J. Cofilin determines the migration behavior and turning frequency of metastatic cancer cells. J Cell Biol. 2007 Nov 19;179(4):777-91.


24. El-Sibai M, Nalbant P, Pang H, Flinn RJ, Sarmiento C, Macaluso F, Cammer M, Condeelis JS, Hahn KM, Backer JM. Cdc42 is Required for EGF-Stimulated Protrusion and Motility in Carcinoma Cells. J Cell Sci. 2007 Oct 1;120(Pt 19):3465-74.


25. El-Sibai M.*, Yip SC*, Coniglio S.J., Mouneimne G., Eddy R.J., Drees B.E., Neilsen P.O., Goswami S., Symons M., Condeelis J.S and Backer J.M. The Distinct Roles of Ras and Rac in PI 3-Kinase Dependent Protrusion During EGF-Stimulated Cell Migration. J Cell Sci. 2007 Sep 1;120(Pt 17):3138-46.


26.  El-Sibai M and Backer J. Phospholipase Cg negatively regulates Rac/Cdc42 activation in antigen-stimulated mast cells. Eur J Immunol. 2007 Jan;37(1):261-70


27. El-Sibai M*, Yip SC*, Hill KM, Wu H, Fu Z, Condeelis JS, Backer JM. Over-expression of the p110beta but not p110alpha isoform of PI 3-kinase inhibits motility in breast cancer cells. Cell Motil Cytoskeleton. 2004 Nov;59(3):180-8.


28. Homaidan FR, El-Sabban ME, Chakroun I, El-Sibai M, Dbaibo GS. IL-1 stimulates ceramide accumulation without inducing apoptosis in intestinal epithelial cells. Mediators Inflamm. 2002 Feb;11(1):39-45.